Phenol Synthesis: Cumene and Dow Processes
Illustrative AI-precomputed disconnections only. Use the planner for evidence-ranked routes with literature when available.
Target: Phenol (C6H6O) · CAS 108-95-2
Share: https://reaction.chemicaltool.com/es/routes/phenol ·
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Step 1 (Cumene process (industrial)):
Cleavage of cumene hydroperoxide yields phenol and acetone (Hock rearrangement).
Reactants:CC(C)(OO)c1ccccc1
Products:Oc1ccccc1.CC(C)=O
No literature evidence -
Step 2 (Aryl halide hydrolysis):
Hydrolyze chlorobenzene under forcing conditions (Dow process style) to phenol.
Reactants:Clc1ccccc1
Products:Oc1ccccc1
No literature evidence
References & tools
- ChemicalTool Reaction — AI retrosynthesis with optional library evidence.
- PubChem — compound identifiers and structure depictions (NIH/NCBI).
- Related: AiZynthFinder / synthesis planning literature for computer-aided retrosynthesis.