Paracetamol (Acetaminophen) Synthesis

Illustrative AI-precomputed disconnections only. Use the planner for evidence-ranked routes with literature when available.

Target: Acetaminophen (C8H9NO2) · CAS 103-90-2

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1. Step 1 (Amide formation): Acetylate 4-aminophenol with acetic anhydride (or acetyl chloride) to give acetaminophen.
   Reactants: Nc1ccc(O)cc1.CC(=O)OC(C)=O
   Products: CC(=O)Nc1ccc(O)cc1
   No literature evidence
2. Step 2 (Nitro reduction): Reduce 4-nitrophenol to 4-aminophenol (e.g. catalytic hydrogenation or Fe/HCl).
   Reactants: O=[N+]([O-])c1ccc(O)cc1
   Products: Nc1ccc(O)cc1
   No literature evidence