Aspirin Synthesis from Phenol

Illustrative AI-precomputed disconnections only. Use the planner for evidence-ranked routes with literature when available.

Target: Aspirin (C9H8O4) · CAS 50-78-2

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1. Step 1 (Esterification): Acetylate salicylic acid with acetic anhydride (often catalytic acid) to give aspirin.
   Reactants: Oc1ccccc1C(=O)O.CC(=O)OC(C)=O
   Products: CC(=O)Oc1ccccc1C(=O)O
   No literature evidence
2. Step 2 (Kolbe–Schmitt (conceptual)): Prepare salicylic acid from phenol via carboxylation at elevated temperature and pressure.
   Reactants: Oc1ccccc1
   Products: Oc1ccccc1C(=O)O
   No literature evidence